Therapeutic administration occurred 6☐.5 hours after injury. Investigators who administered the therapeutic and performed outcome assessments were blinded to group using identically appearing intravenous solutions. All 71 rats received the allocated therapeutic, complete data was obtained for 68, and three histological data sets were uninterpretable. 78 rats were subjected to experimental injury, 5 were excluded for technical reasons, 3 died, and 71 were randomly assigned to groups using a random number generator. control with p<0.05 after correction for multiple comparisons. Sample size was 13 rats per group, based on Monte Carlo simulations which indicated >80% power to detect both an overall significant effect of the repeated measures ANOVA (the primary statistical analysis) and a post-hoc difference between the best performing experimental group vs. The study design and analytic plan were preregistered at the Center for Open Science (). Pathophysiological Mechanistic Studies PapersĮxample “Transparency, Rigor and Reproducibility Summary”:.Please reference the following links for full details for: The statement should be provided in a 500-word limit “Transparency, Rigor, and Reproducibility Summary', placed after the Conclusion.Īn example is below. Starting on January 1, 2023, all manuscript submissions to the Journal of Neurotrauma must include a Transparency, Rigor, and Reproducibility Statement. Word limits do NOT pertain to the abstract, disclosure statements, author contribution statements, funding information, acknowledgments, tables, figure legends, or references. Reference citations are identical in style to those of full original articles, but should not exceed five (5).Maximum of two (2) tables and/or figures.Unstructured abstract of no more than 250 words.Unstructured abstract of no more than 450 words.Manuscripts submitted without this information will be unsubmitted and the submitting author will be asked to add the required components. Please note that there are certain compulsory elements (i.e.: IRB approvals, author disclosures, etc.) for all new submissions. However, after the initial peer review process, revised submissions must follow correct journal formatting and file guidelines, as described below in the Instructions for Authors. Newly submitted manuscripts will not be unsubmitted for formatting issues. Please note that the Journal welcomes format-neutral manuscripts for first-time submissions. Review Articles- Reviews are invited and will be considered. Case reports are not accepted by the Journal. Journal of Neurotrauma will consider original research articles, reviews, short communications, and letters to the editor. Both laboratory and clinical studies are encouraged. Articles published in this journal emphasize morphological, physiological, and biochemical studies of injured neurons and glial cells, mechanisms, and treatments of acute and chronic injury of the nervous system, neural and glial regeneration, transplantation, in vivo and in vitro injury models, cellular growth factors, blood flow, and metabolism of injured nervous tissues, and recovery of function. This includes the anatomy, biochemistry, biophysics, immunology, pathology, pharmacology, and physiology of brain, spinal, and nerve injury. The Journal of Neurotrauma publishes articles dealing with all aspects of neurotrauma. NNS Members Click Here for Submission InstructionsĮNO Members Click Here for Submission Information Average time to initial decision: 25 days.Instant Online Option (immediate publication of accepted version): Yes.File formatting requirement stage: Upon revision.

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